The molecular pathogenesis of Ewing's sarcoma.
نویسندگان
چکیده
Ewing sarcoma family tumors (ESFT) are a group of aggressive solid bone and soft tissue malignancies of children and young adults characterized by specific chromosomal translocations that give rise to EWS-ETS aberrant transcription factors. Identification of EWS-ETS target genes and their role in tumor signaling networks together with the unravelling of the cell of origin will facilitate the translation into new treatment modalities for these neoplasms.
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ورودعنوان ژورنال:
- Cancer biology & therapy
دوره 9 9 شماره
صفحات -
تاریخ انتشار 2010